主要奖项提名名单如下：

Song of the Year

• “Poker Face” - Lady Gaga
• “Pretty Wings” - Maxwell
• “Single Ladies (Put A Ring On It)” - Beyonce
• “Use Somebody” - Kings of Leon
• “You Belong With Me” - Taylor Swift

• “I Gotta Feeling” - The Black Eyed Peas
• “We Weren’t Born To Follow” - Bon Jovi
• “Never Say Never” - The Fray
• “Sara Smile” - Daryl Hall & John Oates
• “Kids” - MGMT

• Black Ice - AC/DC
• Live From Madison Square Garden - Eric Clapton & Steve Winwood
• 21st Century Breakdown - Green Day
• Big Whiskey And The Groogrux King - Dave Matthews Band
• No Line On The Horizon - U2

• “Best I Ever Had” - Drake
• “Beautiful” - Eminem
• “D.O.A. (Death Of Auto-Tune)” - Jay-Z
• “Day ‘N’ Nite” - Kid Cudi
• “Casa Bey” - Mos Def

• “Halo” - Beyonce
• “I Gotta Feeling - The Black Eyed Peas
• “Use Somebody” - Kings of Leon
• “Poker Face” - Lady Gaga
• “You Belong With Me” - Taylor Swift

• Adele (for “Hometown Glory”)
• Beyonce (for “Halo”)
• Katy Perry (for “Hot N Cold”)
• Pink (for “Sober”)
• Taylor Swift (for “You Belong With Me”)

• John Legend (for “This Time”)
• Maxwell (for “Love You”),
• Jason Mraz (for “Make It Mine”),
• Seal (for “If You…”)
• Stevie Wonder (for “All About The Love Again”)

• Zac Brown Band
• Keri Hilson
• MGMT
• Silversun Pickups
• The Ting Tings

• I Am… Sasha Fierce (Beyonce)
• The E.N.D. (BEP)
• The Fame (Lady Gaga)
• Big Whiskey And The Groogrux King (Dave Matthews Band)
• Fearless (Taylor Swift)